Word: hyperlipidemia
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Earlier human trials have shown, however, that rapamycin can have serious side effects. Because it is an immunosuppressant, it can make users susceptible to opportunistic infections. It has also been linked to hyperlipidemia, or high levels of triglycerides in the blood, which can lead to heart disease. It's unclear whether these problems would counteract any longevity benefit that rapamycin might provide in humans. Says Strong, "I think more immediately, people are starting to look at [rapamycin] for age-related diseases like Alzheimer's disease, Parkinson's disease or kidney disease." The drug has also recently entered clinical trials...
...While the guidelines target kids with a genetic risk of abnormally high cholesterol, called hyperlipidemia, they could lower the bar for prescriptions - not just for these children but for any overweight youngster whose cholesterol is not in check. Within hours of the AAP announcement on July 7, parents took to the blogs, expressing shock and unease over the aggressiveness of the guidelines. Statins are not without risks; in adults, in rare cases, they can cause muscle weakness and kidney problems, and there are limited data on how statins affect children...
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