Word: giardiello
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Nichols' story is remarkable. He not only fought for the drug's development in the face of total disinterest by drugmakers and mainstream cancer scientists but may also have opened the door to a whole new family of cancer drugs. Says Dr. Francis Giardiello, chief of gastroenterology at Johns Hopkins: "He spurred them to look into this a lot deeper and a lot faster than they would have otherwise. He has a proud legacy." He may also posthumously save the life...
...thought to be a disease of uncontrolled growth. Nichols' scientists suspected instead that the problem was uncontrolled death. Cells lining the intestines usually live only 72 hours. But while cells are born at the usual rate in FAP patients, some fail to self-destruct, producing an excess. Johns Hopkins' Giardiello eventually showed that drugs like sulindac work by restoring the natural process of cell death in the colon. Precisely how it does that, however, remains unknown...
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