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...From an initial result involving thousands of different proteins, researchers narrowed the potential candidates by comparing the 12 samples to those from healthy children without appendicitis. "We analyzed the proteins to see which were statistically significant compared with [the controls], and this gave us a short list," explains Hanno Steen, director of the Proteomics Center at Children's and a co-author of the study. That short list, combined with other possible protein candidates identified in previous research on the subject, comprised 57 different possibilities. (See the top 10 medical breakthroughs...

Author: /time Magazine | Title: A Urine Test for Appendicitis | 6/23/2009 | See Source »

...Over the next 18 months, researchers analyzed urine samples from 67 pediatric patients who came to Children's emergency room with possible cases of appendicitis. Of those, 25 were confirmed to have the sharply painful condition; samples from the other patients were used as controls. Steen explains that in an emergency room situation, physicians are often faced with distinguishing appendicitis from conditions involving abdominal pain, so it made sense to mimic this contrast in the protein analysis as well...

Author: /time Magazine | Title: A Urine Test for Appendicitis | 6/23/2009 | See Source »

...Before becoming the first African-American elected to statewide office in Maryland in 2003, Steele worked as a corporate securities attorney at the law firm of Cleary, Gottlieb, Steen & Hamilton in Washington...

Author: /time Magazine | Title: New RNC Chairman: Michael Steele | 2/2/2009 | See Source »

...Jason Steen isn't an obvious target for muggers. The 40-year-old heads his own company advising on mergers and acquisitions, and usually strides through life like a Master of the Universe. This evening, though, he looks shaken. Two days earlier, he was accosted outside his central London home by eight kids - the youngest was 11 - who punched him to the ground, hustled him to the nearest cash machine and forced him to reveal his PIN number. After a series of attacks in the area, local residents have gathered in Steen's apartment to talk to the policeman handling...

Author: /time Magazine | Title: Britain's Mean Streets | 3/26/2008 | See Source »

...politics, the media and the heartbroken ranks of victims' families says the way to do this is to get tougher with children in trouble rather than coddle them. It is true that the criminal justice system does not inspire much confidence. Some cases never come to trial at all. Steen's assailants were not charged. "The police knew who the perpetrators were, but were powerless to act. The burden of proof is so great," he says...

Author: /time Magazine | Title: Britain's Mean Streets | 3/26/2008 | See Source »

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