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Realizing that potential - and with it, the prospect of successful treatments for conditions like Parkinson's or diabetes - may still be a few years away. Even iPS cells have yet to prove that they are a safe and suitable substitute for the diseased cells they might eventually replace in a patient. Ensuring their safety would require doing away with dangerous genes that can also cause cancer, as well as the retroviral carriers that Yamanaka originally used. Melton's team has already replaced two of the genes with chemicals, and he anticipates that the remaining ones will be swapped...
Even if iPS cells do not prove as stable and as versatile as embryonic stem cells when they're transplanted into patients, they remain a powerful research tool. And if nothing else, they will have opened our eyes to the remarkable plasticity of biology and made possible new ways of thinking about repairing and replacing damaged tissues so we may consider not only treating but also curing disease. "It's a wonderful time," says Scadden. "Keep your seat belt on, because this ride is going to be wild...
...plenty of soapboxes one can stand upon, but one of them is not a short story." In the world of In Other Rooms, all politics is local: the never-ending battle against corruption, the violence that erupts over a cherished motorcycle, the arguments between newlyweds whose outlooks on life prove crushingly incompatible...
...Mitchell appointment will probably prove controversial among Israel's neoconservative American supporters - and, quite possibly, with Israel's government, especially if the Likud Party wins the Feb. 10 elections. To Likudniks, the very act of naming an envoy is suspicious: Mitchell is likely to do something the Bush Administration rarely did - ask for Israeli concessions, however minor. The Mitchell appointment and the Al Arabiya interview are of a piece: respect will be paid to Muslims by the Obama Administration. The long-term goal is to weaken the regional tyrants and extremists by depriving them of the Great Satan caricature...
...First Minister and leader of the Democratic Unionist Party, called the idea of the recognition payment "offensive." Nationalists and Republicans raised concerns that some recommendations could block future investigations into killings that may have involved collusion between security forces and paramilitaries. Such opinions will be registered, but may not prove decisive. Northern Ireland has come a long way, but ten years after devolution, the final judgment on the proposals lies with Westminster and Dublin...