Word: processing
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Dates: during 2000-2009
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...Linney takes the lead as Sammy, a small-town bank manager who was orphaned as a girl and who's still experiencing growing pains as a single mom with a little boy (Rory Culkin), a wayward younger brother (Mark Ruffalo) and a frustrating new boss (Matthew Broderick). In the process, Linney produces some of the year's most indelible acting moments. Watch her drive alone from an ill-advised rendezvous with her boss and see the emotions illuminate Linney's face like flickering candles--a smile, a jolt of sadness, a surge of joy. "She made a little play...
Mongomusic has the most sophisticated approach to divining your tastes. Here you pick your favorite songs, and the site will play tunes that sound similar, regardless of artist or genre. It's a laborious process, but the potential rewards are tremendous. Give it an hour of your time, and you'll feel like Radio Me is on the air, free of cookie cutters and rankings. If they'd only fix the sound quality, its pitch would be perfect...
...Beecham are racing to develop similar compounds. The reason? Over the past five years, an explosion of insights into the genetics of Alzheimer's has bolstered confidence that gamma secretase and a related enzyme called beta secretase are not innocent bystanders but rather are intimately involved in the disease process...
Tumors, it turns out, cannot grow much beyond the size of a peppercorn without an ever expanding network of blood vessels. Clinicians are testing more than a dozen treatments aimed at halting that process, including some old-line drugs that have turned out to have antiangiogenic properties. Thalidomide, which caused devastating birth defects in some 12,000 children worldwide before it was withdrawn in the early 1960s, is finding a new lease on life against multiple myeloma and liver cancers. Pharmaceutical giant Bristol-Myers Squibb is testing an antiangiogenic drug that was initially developed to keep cancer from worming...
Researchers are also searching for new drugs to dampen the inflammation process. The goal of such treatments is not so much to remove a fatty plaque from inside an artery but rather to convert it from a more dangerous form to a more stable one. This may be one of the reasons a daily dose of aspirin, which is both an anti-inflammatory and a blood thinner, can help prevent heart attacks. But doctors would like to have a drug that targets coronary inflammation more specifically and aggressively than aspirin...