Word: problem
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...doctors, most headache patients are a pain because there are dozens of possible causes. With migraine patients, the problem is quite different; while sufferers can pinpoint certain triggers (food, sleep patterns, stress, alcohol), no one's really sure what exactly causes the condition in the first place. The headaches can last hours - sometimes days - and often come with nausea, vomiting, sensitivity to sound and light, and, perhaps most strangely of all, distorted sensory perception, especially vision. Add to that a link with certain other blood conditions and neurological conditions, and it's no surprise that researchers are still perplexed about...
...overly sensitive nerve cells are the problem, it makes sense to try to calm them down--and that's exactly what the first drug tailored to block an oncoming migraine was designed to do. Approved in the U.S. in 1993, sumatriptan mimics the action of a neurotransmitter called serotonin, which plays many roles in the brain, including regulation of mood and pain. In the case of migraines, the drug prevents nerve endings in the dura from releasing their stimulatory proteins. No proteins, no pain...
...migraine sufferers and opened up promising areas of research. Scientists have discovered that triptans, besides affecting serotonin pathways, also directly block one of the stimulatory proteins released by the nerve endings in the dura. New compounds that target this protein, dubbed cgrp, are being tested in Europe. One big problem, says Lars Edvinsson of Lund University in Sweden, "is that the drug can be given only intravenously. We need a cgrp blocker that works as a tablet...
...Pain Management Center at the University of California in San Francisco. "Initially it helps, but over time the headaches get worse." Painkillers that contain caffeine are the most common cause of such rebound headaches. Taking baby aspirin to prevent a heart attack does not seem to be a problem...
...contract to take the class, which targets middling students, those "on the edge of being successful," explains Euel Bunton, principal of Phillips. While results of the program aren't yet in, attendance of AVID students is 90% - a promising sign in a school where chronic truancy has been a problem...