Word: pam
(lookup in dictionary)
(lookup stats)
Dates: all
Sort By: most recent first
(reverse)
...Pam-Pam Pioneers...
...Paix article was very interesting; however; the information respecting the Pam-Pam restaurants is inaccurate. I alone am responsible for the creation of the name, as well as the creation of the Pam-Pam restaurants. I am still sole owner for the rights of the name Pam-Pam...
Around the Corner, Pam-Pam. But for the Café de la Paix. the end of World War II nearly proved disastrous. As prices skyrocketed, the carriage trade moved on to less expensive places; Frenchmen still crowded the chestnut-shaded sidewalk tables, but they dawdled longer over aperitifs or coffee, and U.S. tourists were warned off by the high prices noted in guidebooks. The Café de la Paix might have toppled like a French Cabinet had it not been for energetic Paul Chapotin, 41, son-in-law of the restaurant's second-generation owner, 74-year-old Andr...
Like many another medical victory, the development of PAM (2-pyridine al-doxime methiodide) was the unplanned result of basic research. First, Columbia's Dr. David Nachmansohn showed that the enzyme cholinesterase (one of the body's catalysts) is essential for the transmission of nerve impulses. Trying to learn more about cholinesterase, Biochemist Irwin B. Wilson discovered that nerve gases (and certain insecticides) cause death by adding to the nerve cell's cholinesterase something that damages it. The something is a phosphoryl that destroys the nerves' ability to transmit impulses to muscles...
...Wilson tried several known compounds as antidotes. They did not work fast or well enough, so he and a research team set out to design a completely new compound that would reactivate cholinesterase by getting close to the phosphoryl group and removing it from the cell's protein. PAM got its test when hundreds of mice were exposed to one of the most deadly nerve gases, then given shots of the compound. The results, reported the researchers, were "dramatic and certain." Not a mouse died. Since protein structure is the same in humans and mice, scientists see no reason...