Word: jolla
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...Captain Will Rogers III, commander of the U.S.S. Vincennes, the guided-missile cruiser that mistakenly shot down an Iranian passenger jet last July, killing all 290 passengers and crew members. Eight months later, his wife was driving to her job as a fourth- grade teacher at the elite La Jolla Country Day School. As she paused for a red light, Rogers heard a bang in her Toyota van; she leaped out, unharmed, just before the vehicle burst into flames. Investigators believe a terrorist pipe bomb was placed in the van in retaliation for the downing of the Iranian airliner...
...pair of remarkable studies, one reported in the journal Nature and the other to be published in Science this week, researchers at the Medical Biology Institute in La Jolla, Calif., and at Stanford University, working separately and using different methods, successfully transplanted elements of the human immune system into mice. The achievement meant that such animals may soon serve as stand-ins for human beings in the study of AIDS and a host of other diseases, including leukemia and hepatitis. The mice could also be used to test drugs that would be unsafe to test in humans and to study...
...Jolla team also used SCID mice. By comparison, however, their approach was simple. Circulating white blood cells taken from human adults were injected into mice. Almost immediately, the mice began replicating the cells. Within three weeks they had human immune systems with nearly correct proportions of all the major types of white cells found in human blood. Moreover, when the researchers injected these mice with tetanus toxoid, most of the animals produced human antietanus antibodies, further proof that their new immune systems were functioning as though they were naturally human...
...expect them to reject the transplanted human cells. Researchers also suspected that the human fetal cells, since they are too immature to distinguish themselves from foreign cells, would not reject the mice in a graft-vs.-host response. But, surprisingly, the adult human cells used in the La Jolla research did not reject the mice either. "That these human cells recirculate around in the mice without caring is astounding," said Dr. Donald Mosier, head of the La Jolla research team...
Mosier's research bore some relevance to the discussions under way at the NIH meeting. While the Stanford work with fetal tissue appeared to be a powerful argument for continuing such experimentation, the La Jolla studies seemed, however unintentionally, to offer an alternative. Still, Daniel Koshland Jr., editor of Science, who admitted to releasing the Stanford results a week early in order to coincide with the NIH meeting, strongly backed the scientists' right to continue their research. Said Koshland: "This is an excellent example of careful, scientifically controlled use of fetal tissue to attack major human disease." Moreover, the fetal...