Word: hms
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...HMS investigators analyzed 696 participants from the Physicians Health Study--a study of 22,000 health professionals conducted at the Brigham and Women's Hospital since 1982-half of whom had experienced strokes. The HMS investigators used a person's age and whether or not he or she smoked as categories to compare the 348 individuals who experienced strokes with...
Another team of HMS researchers has discovered an early step in the stroke's deadly pathway. Their study, which has the potential to provide a potent new target for drug therapies, is published in this week's issue of the Proceedings of the National Academy of Sciences...
However, a team of researchers led by Beverly M. Murray, an HMS research fellow in neurology, and Edwin J. Furshpan, Robert Pfeiffer professor of neurobiology at HMS, have discovered that a member of the MAP kinase family known as ERK may be involved in the activation of one or more of these excitotoxic pathways...
...HMS investigators mixed cultured brain cells with an ERK-blocking drug, PD098059, and induced seizures in the cells (seizures are also thought to utilize excess glutamate to promote death in neighboring cells). They found that when the ERK was blocked, the cells were safe from deadly glutamate exposure...
...HMS press release, Allessandro Alessandrini, assistant biologist at Massachusetts General Hospital and a co-author of the study, says, "The exciting thing about this is not only that it deciphers an initial stage in the pathway of stroke, but also suggests that a pathway thought to be involved in cell proliferation may lead to damage early on in ischemia...