Word: geneses
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The three new genes, known as clusterin, complement receptor 1 (CR1) and PICALM, were uncovered by two separate research groups, one in Wales and one in France, who linked the genes to the most common form of the memory disorder, late-onset Alzheimer's - the type that affects patients in...
In the current studies, researchers amassed the largest set of genetic data to date in the study of Alzheimer's, and took advantage of the most recent advances in genetic screening to determine which new genes conferred a high risk of developing the disease. "I think this technique is going...
Williams's group collected 16,000 DNA samples from Alzheimer's patients and healthy controls, while the French team, led by Dr. Philippe Amouyel at the Pasteur Institute, gathered more than 7,000 similar samples. Each team worked independently, unaware of the other lab's research, until both happened to...
Each group came to their separate conclusions the same way, comparing the genetic activity of their thousands of samples. Williams's team found that among the Alzheimer's patients' samples, certain versions of the genes that coded for clusterin and PICALM were more likely to be active, compared with the...
The discoveries mark a significant step forward in Alzheimer's research - until now, three of the four known genes associated with the disease were connected to the rarer, inherited form, which appears in adults as young as 40 or 50. The three additional genes, identified in the new papers, now...