Word: fibrinogen
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Dates: during 1960-1969
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Clotting Factor. To explain the higher blood viscosity of Raynaud's victims, the Walder group now indicts an excess of fibrinogen, one of the several substances involved in the blood-clotting mechanism, and a major factor in blood sludging. On this theory, the surgeons are treating 40 patients with intravenous drips of blood thinners ("plasma expanders") and anti-clotting drugs. The researchers claim no dramatic effects, but report cautiously that these treatments have improved the patients' peripheral circulation, "at least temporarily." In the more serious cases, they say, the treatments "were of considerable value...