Word: crestor
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Segal was one of 24 million people taking drugs to lower cholesterol in the U.S. that year. The workhorse of American medicine, statins - first sold in the U.S. in 1987 and marketed under brand names like Lipitor, Zocor and Crestor - are designed to clear away LDL cholesterol, the waxy buildup that can clog arteries and trigger heart attacks and strokes. Doctors say the majority of current statin users are healthy people who don't have heart disease but who, like Segal, simply have high cholesterol. Use among this group, known as the primary prevention population, has made these drugs...
...Jupiter TrialGrundy says he now has the evidence he's been waiting for. In a paper published in February in the journal Circulation, researchers analyzed data on women who took part in the Jupiter trial, a large, industry-funded study that sought to compare the effectiveness of the statin Crestor (rosuvastatin) with that of a placebo in healthy patients. The study, which ended in 2008, involved nearly 18,000 participants - including 6,801 women, more than in any previous statin trial - who had high levels of C-reactive protein, a risk factor for heart disease, but did not have high...
...Boston, the study tracked about 17,800 people in 26 countries. Participants included men ages 50 and older and women ages 60 and older, who had high levels of C-reactive protein (CRP) but normal cholesterol levels and no history of heart disease. Half the participants were given rosuvastatin (Crestor), and half were given a placebo daily for just under two years. The statin group reduced their CRP levels by 37%; their LDL, or bad cholesterol, levels dropped 50% to about 55 mg/dL. Among the 8,901 statin-takers, 31 suffered a heart attack and 33 suffered a stroke. When...
...likely to dial back on their use of Vytorin. "If they aren't getting to the target goal [cholesterol level] with generic simvastatin, then because this study is raising questions I think a lot of physicians will think about switching to higher doses of drugs like Lipitor or Crestor before going to Vytorin," says Blumenthal. At least the commercials got one thing right - your risk of heart disease does depend on the food you eat and the genes you inherit. It's just that Vytorin may not be best way to fight those factors when it comes to keeping your...
...They barely get a second thought these days. The dreaded side-effects just aren't that common. For reasons never clear to the surgeons, new drugs catch on in waves; first it was Prozac, then Zoloft, now its Lexipro. All our patients were on Lipitor, now they're on Crestor. Treating numbers like bone density and LDL cholesterol instead of treating fractures and clogged arteries is hopefully an improvement, so a new generation of patients goes to the doctor, not to get well but rather to not get sick...