Word: compounding
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Unless you're in the market for a pair of modestly priced loafers, Marikina Shoe Expo may not sound like a promising destination. But while you can always visit for bespoke leather brogues or inexpensive PVC pumps, this U-shaped compound, nestled in Manila's sprawling Cubao district, offers more than just footwear. Built in the 1970s, at the behest of the Philippines' footwear-loving former First Lady Imelda Marcos, who wanted to promote local shoemakers, it seemed on the brink of dereliction when its original tenants began to close down due to cheap Southeast Asian competition. Rents plummeted...
...hour that most of the owners, being night owls, prefer to commence business. "It's completely different from a mall - it's still independent and nonmainstream," says indie filmmaker Bong Salaveria. His appointment-only antique store, Vintage Pop, was one of the vanguard establishments of the newly recolonized compound. Salaveria closed it in July - he is about to emigrate to Canada - but Vintage Pop's range of 20th century kitsch, which Salaveria sometimes customized, was emblematic of the kind of thing Cubao X trades in. So was the store's whimsical approach to retailing. Customers grew accustomed to having...
...stands as a stronghold of hip, culture-savvy, creative Manila - most conspicuously on Friday and Saturday nights, when avant-garde DJ sets, indie-rock gigs, poetry readings, independent-movie screenings and art-show openings spring up as if spontaneously. Yet even without an event on the cards, the compound's motley venues offer plenty of diversions. It's hard not to find joy within the expansive Grand Thrift House, tel: (63) 920 962 3079, run by a family of antique and curio collectors - expect vintage Elvis posters, brick-sized cell phones and secondhand photography books (if you're lucky...
...activity of bone-destroying cells, denosumab prevents new ones from forming altogether. The end result is a tipping of the bone balance away from bone destruction and toward bone formation. Early studies in mice at Amgen, the company that developed denosumab, showed that animals given higher amounts of this compound developed thicker, more robust bone...
Amgen is developing an anabolic therapy based on a genetic mutation found in people with abnormally strong bones. So far, says the company's executive vice president of research and development, Roger Perlmutter, early testing of the compound in postmenopausal women has been "spectacular." The agent appears to build bone density, and Perlmutter's team is continuing to study the volunteers to see if they experience improvements in fracture healing...