Word: compounded
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Dates: during 1980-1989
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...suicide driver crashes an explosive-laden truck into the U.S. compound, killing 241 U.S. servicemen...
Even as the FDA was easing its rules, AIDS sufferers were still searching for a cure on the black market for unapproved drugs. It was revealed last week that an underground network of doctors in four cities has been conducting a clandestine trial of a drug known as Compound Q. In test tubes, it can destroy cells infected with the AIDS virus, but it has not yet been proved to be safe and effective in humans. In the unofficial trial, 42 patients have received Compound Q, which is derived from a Chinese cucumber-like plant. Among those taking the drug...
...secret study, organized by a San Francisco-based group of AIDS activists called Project Inform, came to light after one of the patients died. He went into a coma, later awoke but then choked while vomiting -- ten days after his first Compound-Q treatment. The FDA has launched an investigation of the study...
...Compound-Q affair has heightened concern about the widespread use of unproven drugs. "There is always a tension between treatment of a patient and the need for solid drug testing," says Dr. Frank Young, the FDA commissioner. But AIDS has increased that tension. Those with the disease have protested for years that the FDA's traditional methods of testing an experimental drug's safety and effectiveness were too slow. "People have lost faith in the system," says Richard Dunne, executive director of Manhattan's Gay Men's Health Crisis...
...concerned that the use of unproven medications may be getting out of control. So many AIDS patients are taking a pharmacological stew of approved and experimental drugs and potions that it is difficult to gauge the effectiveness of any single drug. Underground studies of experimental drugs, like the Compound-Q effort, confuse an already complex situation and frustrate scientists. "They're violating all the standards of safe testing of new compounds," says Dr. Paul Volberding, an AIDS specialist at the University of California at San Francisco. The haphazard use of experimental drugs may help some AIDS patients in the short...