Word: compounded
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Dates: during 1940-1949
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...early as 1941, Drs. Hench and Kendall speculated that an unknown "anti-rheumatic substance X" might be a hormone from the adrenal glands. In 1946, with the help of Merck & Co. chemists, they developed a compound from the adrenal glands of cattle. It was called Compound E (full name: 17-hydroxy-11-de-hydrocorticosterone). Compound E belongs to the steroid group of body chemicals. So do the sex hormones (a link with relief during pregnancy) and some bile products of the liver (a link with jaundice). Compound E was obtained later from an element of bile. Seven months ago Mayo...
...ACTH. The results were dramatic but, like the results of earlier work, they were fleeting. Fifteen patients, some unable to walk, showed great improvement soon after injections of large doses of Compound E (as much as 100 milligrams a day). The first patient was a woman who was barely able to get out of bed. By the third day she was walking with only a slight limp; a week later, pain and muscular stiffness had almost disappeared. But improvement ended when the drug was stopped. After varying periods without the drug, the patients were back where they started. Two other...
...soon after she left school. She was assigned to the chloromycetin research project in 1947. After two years of testing, she became the first to isolate a synthetic form of chloromycetin that worked on human patients. The life-saving antibiotic contains two chemicals which are normally poisonous: a nitrobenzene compound and a derivative of dichloracetic acid, now used chiefly for getting rid of warts...
There was no doubt about the "master-publisher" part: Hutchinson's publishing and printing firms put out about 10 million books a year-from Calcium Superphosphate and Compound Fertilizers, by P. Parrish, to The Gamester, by Rafael Sabatini-and have brought him a fortune exceeding ?4,000,000. And there was no doubt that he had overcome plenty of difficulties-in person. For five years he had haunted the auctions, picked every painting and print himself, without a moment's doubt of his judgment. He knew what he wanted: "But of course! I own horses; I know what...
...Haagen-Smit believes that the shape of a compound's molecule is important in determining what it smells like. The nose, he thinks, contains "receptors" which are designed to respond to molecules of certain shapes. When one of these comes along, the receptor recognizes it by its shape, and sends a nerve message which the brain interprets as an odor...