Word: close
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Dates: during 1990-1990
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Nothing in the theater is ever a sure bet, but Clavell always believed Shogun was close to it. The 1975 novel sold 15 million copies worldwide. The ; 12-hour TV version, seen by more than 130 million in the U.S., was the nation's fourth most watched mini-series ever, and proved just as popular in Japan (whence came the bulk of the musical's financing). Says Clavell: "It's got a love story and, obviously, opportunities for high adventure. In production values it should compare quite favorably with Les Miserables and The Phantom of the Opera." So he financed...
...Health launched a clinical trial to assess the connection between blood-sugar levels and the development of complications. Half the 1,441 volunteers are following the standard policy of two insulin * shots a day. The rest belong to an intensive-therapy group that tries to keep blood sugar as close to normal as possible. Some participants, like Ken McDonald, are using insulin pumps. Others inject themselves with insulin four times a day. The results, scheduled for release in 1993, should determine whether or not the benefits of intensive therapy outweigh the risks. Cautions Dr. Saul Genuth of the Mount Sinai...
...years medical researchers have dreamed of not just controlling diabetes but preventing it. For Type I diabetes that goal seems tantalizingly close. Like multiple sclerosis and rheumatoid arthritis, Type I diabetes is known to be an autoimmune disorder. What this means is that the insulin-producing areas of the pancreas are attacked by the very cells charged with protecting the body from viruses and other invaders...
...sign that an autoimmune attack has begun is the appearance in the bloodstream of antibodies to the pancreatic cells and, later, to insulin itself. For nine years a Joslin Center research team led by immunologist Dr. George Eisenbarth has been tracking the appearance of these antibodies in 10,000 close relatives of Type I diabetics. It is now possible for the Joslin team to predict which otherwise symptomless relatives are likely to develop the disease in three years' time. Last May the Joslin and two other medical centers launched a program to treat identified potential diabetics with an antirejection drug...
...bring their blood sugar back to normal by dropping a modest amount of weight. But not many succeed. Even more than Type I, Type II diabetes appears to run in families. If both parents develop the disease before middle adulthood, the chance a child will contract it runs close to 80%. Diabetes is endemic among many American Indian tribes, notably the Pima Indians of southern Arizona, who have the highest incidence of Type II diabetes in the world (50% of those over...