Word: bones
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...three straight years Kansas City waged war with the New York Yankees, trading bone-jarring slides, brush-back pitches and dramatic home runs. The Royals-Yankees match quickly became one of baseball's fiercest showdowns, but it was always the New Yorkers who went to the World Series. The Phillies were even more conspicuous failures in the stretch. In 1964 they set an unenviable standard for September swoons, blowing a big lead by winning only four games in the season's final 2½ weeks. The last time the Phillies won a pennant, in 1950, they were wiped...
Just this past spring, scientists at U.C.L.A. announced that they had inserted foreign genes into the bone-marrow cells of mice, the first attempt at using new genetic-engineering techniques with living animals. But experiments on humans, experts said, were still years away. Not so. Last week it was disclosed that the great divide between research in mouse and in man had been quietly crossed...
...July, U.C.L.A. Hematologist Martin Cline and colleagues at Jerusalem's Hadassah Hospital on Mount Scopus and at a clinic of the University of Naples performed gene transfers on two female patients. Both had severe thalassemia, an inherited blood disorder in which the bone marrow produces red cells with defective hemoglobin (the molecule that carries oxygen to body tissues). Victims need frequent blood transfusions, but this leads to a buildup of iron in the body, particularly the heart, that can eventually cause death...
Cline and his collaborators treated their patients by removing a small amount of bone marrow and mixing it with genes capable of directing production of normal hemoglobin. The genes had been manufactured by bacteria altered by recombinant-DNA techniques. The marrow cells, now bearing the new genes, were then injected back into the patients. There is as yet no sign that their reconstituted marrow cells are producing healthy hemoglobin. But the story of the experiment, which was broken by the Los Angeles Times, has raised questions about whether the effort was premature. U.S. regulations require investigators to get approval...
...enormous head. From the brow there projected a huge bony mass like a loaf, while from the back of the head hung a bag of spongy fungus-looking skin, the surface of which was comparable to brown cauliflower. . . From the upper jaw there projected another mass of bone. It protruded from the mouth like a pink stump, turning the upper lip inside out and making of the mouth a mere slobbering aperture . . . The back was horrible, because from it hung, as far down as the middle of the thigh, huge, sack-like masses of flesh covered by the same loathsome...