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...could that principle extend to doctors treating patients? "At medical school, I was taught to aim for perfection," says Anthony Rodgers, director of the clinical trials research unit at the University of Auckland. But now Rodgers and others are preparing to show that, when it comes to preventing heart attack and stroke, the way forward for doctors may be to fuss less over drugs and dosages and instead prescribe, for everyone, a single, multi-function pill...

Author: /time Magazine | Title: A Remedy Off the Rack? | 5/10/2007 | See Source »

...cholesterol), and two blood-pressure-lowering agents. When two British researchers pushed the case for the polypill in a 2003 report in the British Medical Journal, they argued that if taken daily by people with vascular disease and those aged over 55, it would cut the incidence of heart attack and stroke by more than 80%. While advocates have retreated marginally from that claim, their enthusiasm is palpable. "In terms of delivering care at the community level," says Anushka Patel, director of the cardiovascular division of Sydney's The George Institute for International Health, "I think it's potentially...

Author: /time Magazine | Title: A Remedy Off the Rack? | 5/10/2007 | See Source »

...balk at the cost, inconvenience or stigma of popping five pills a day. But slackening off can be deadly: between a third and a half of the more than 50,000 Australians (and 11,800 New Zealanders) who die each year from cardiovascular disease have previously survived a heart attack or stroke. As a way to boost compliance, condensing treatment into a single pill, says Patel, "is probably going to be one of the biggest steps forward we can make at this stage." The trials will pit a polypill-based strategy against standard care. The aim: to find out whether...

Author: /time Magazine | Title: A Remedy Off the Rack? | 5/10/2007 | See Source »

...carries the risk of side effects, and these have to be weighed against the potential benefits. For over-55s in excellent cardio health, the net benefit would be minimal. So another study will involve 600 subjects who doctors believe run a 7.5% to 15% risk of having a heart attack or stroke in the next five years, regardless of age. None of them will have cholesterol levels or blood pressure that would qualify them for treatment under current guidelines, just mild to moderate elevation in their readings across multiple risk factors. Treating for overall rather than individual risk recognizes...

Author: /time Magazine | Title: A Remedy Off the Rack? | 5/10/2007 | See Source »

...incumbent, acting Governor Jane Swift, after promising not to run against her; then he sideswiped Democrat Shannon O'Brien. After she accused him of trying to "mask a very conservative set of belief systems," Romney called her "unbecoming," leaving the impression that he considered it a none-too-veiled attack on his religion. He won, 50% to 45%, carrying many of the Democratic areas of the state...

Author: /time Magazine | Title: What Romney Believes | 5/10/2007 | See Source »

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