Word: attackable
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...ENHANCE was never designed to provide outcomes, meaning the prevention of major adverse cardiovascular events such as heart attack or stroke," says Davies. "This was an interesting scientific exercise to look at the impact of the drug on plaque, which is itself a surrogate end point for these events...
ENHANCE may only be the opening salvo against Vytorin - three larger trials are currently under way to measure the drug's effect on heart attack and stroke - and many physicians are not optimistic. "Given these results, it's highly unlikely that those outcomes studies will show dramatic benefit for Vytorin," notes Dr. Raymond Gibbons of the Mayo Clinic, and past president of the American Heart Association...
...could such a drug be approved in the first place? The Food and Drug Administration would only say that it is "evaluating the available data related to the ENHANCE study." That would include the "food and family" advertisements for Vytorin, which claim that the drugs attack high cholesterol levels, whether they come from your diet or from your genes, or some combination of both. Davies says the company has made "no determination at this time" on the fate of that campaign. But it should give the FDA good reason to evaluate how it approves future medications in this class...
...target of Tuesday's attack may have marked it as a turning point in the campaign of political violence that has racked Lebanon since 2004, but the spectacle was grimly familiar: The acrid stench of smoke, the crunching of shattered glass underfoot, pools of black oil from destroyed vehicles, smeared gouts of congealing blood, wide-eyed and angry soldiers and police thrusting back crowds of journalists and onlookers. The car suspected of carrying the bomb was a twisted sculpture of fire-blackened steel. A second car, containing the bodies of two of the victims, appeared to have taken the brunt...
Tuesday's car bomb attack on U.S. embassy vehicle in northern Beirut was relatively ineffective by today's gruesome standards of political violence: The blast killed four people and wounded 20, but none of the American diplomats who were its presumed targets was harmed. Even so, as the first attack targeting U.S. officials in Lebanon since the end of the civil war in 1990, the bombing will send a nervous shudder through the small but growing American community in Beirut...