Word: schizophrenia
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...after years of controversy, dashed hopes and burst stock bubbles, the effort is finally paying off. Over the past decade, deCODE Genetics, the company Stefansson co-founded in his home city of Reykjavík, has discovered more than a dozen genes linked to diseases ranging from stroke to schizophrenia. Last month, deCODE announced that it had found a gene that boosts the risk of Type 2 diabetes. And within a few weeks, the company will start the final phase of trials for a drug based on a newly identified heart-attack gene that appears to be especially dangerous in African...
...National Institutes of Health will look for nearly 20 diseases in up to 40,000 people. But with its long head start and Iceland's genetic advantages, deCODE could be hard to catch. So far the company has isolated 15 gene variants for 12 diseases, including stroke, schizophrenia, osteoarthritis and, most recently, diabetes. In addition to the heart-attack drug, it has medications in the pipeline for preventing asthma and atherosclerosis. Even when no drug is available, knowing you have a disease gene can be invaluable. "What it tells you," says Stefansson, "is whether you are at risk...
...help shift workers stay alert. And there's a lot more in the pipeline. Neurologists have made rapid progress unraveling the molecular underpinnings of memory and attention, and drug companies are testing dozens of compounds derived from those discoveries to treat cognitive ailments like Alzheimer's disease and schizophrenia...
...SCHIZOPHRENIA Americans spend about $10 billion a year for antipsychotic medications, but are we getting our money's worth? Not according to a landmark government-funded trial published in the New England Journal of Medicine. It found that Risperdal, Seroquel and Geodon, three of the new "atypical antipsychotics" that doctors widely prescribe to treat schizophrenia, are no more effective--and no safer--than an older and much cheaper generic drug called perphenazine. The study was another reminder that the flashy new compounds coming out of pharmaceutical labs may not be worth the high price tags they command. Perphenazine, for example...
Psychiatrist: The (schizophrenia) drugs are like insulin for diabetes. Whitaker: No, they're not - you have no confirmed biological problem. Psychiatrist: O.K., that's true. Whitaker: So why say it? Psychiatrist: Well, it gets people to take their drugs...