Word: rosenberg
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Dates: during 1980-1989
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...work combines the efforts of three top NIH scientists: Steven Rosenberg, an expert in cancer therapy, and W. French Anderson and R. Michael Blaese, two master gene manipulators. For several years Rosenberg has been developing a novel cancer treatment using a type of cancer-fighting cell called TILs (tumor-infiltrating lymphocytes). He removes TILs from cancer patients and clones large quantities of the cells in the laboratory. When this army of cells is reinjected into the patients, their tumors can shrink significantly. In one experiment with metastatic melanoma patients, 60% of them benefited from the therapy. But Rosenberg still needs...
That is where gene transplants come in. Anderson has developed a technique using a "marker" that will let Rosenberg follow the progress of the TILs. The marker is the E. coli gene that makes a cell resistant to the antibiotic neomycin. Anderson has been able to tuck that bacterial gene into a virus and then implant the virus into TILs. Once inside the TILs, the gene becomes fully functional...
...upcoming experiment, Rosenberg plans to inject ten terminally ill patients with TILs carrying the marker. Periodically, he will remove bits of tumor from the subjects and douse the samples in neomycin. If some cells survive the dosing, he will know the TILs have reached the tumor...
Stampfer's study received praise from a researcher who is also examining the affect of oral contraceptives on heart disease. "His is a very large study, [which was] well conducted. I think it's a pretty convincing study," said Lynn Rosenberg, director of the Slone Epidemiology Unit at Boston University Medical School...
...Rosenberg said that the findings of a three-year study at the Slone center were consistent with Stampfer's work. "Our preliminary results are very similar to what Dr. Stampfer will publish tommorrow," she said yesterday...