Word: profoundly
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This unwillingness to embrace change has profound and pernicious effects on College life. The clubs’ discriminatory membership policies place the accumulated wealth, real estate, and prestige of dozens of generations in the hands of men alone—and at a school with limited social space, this imbalance warps gender relations into something out of a Jane Austen novel...
Indeed, what is often described as simply a problem of communications strategy in the Roman Curia is in fact much more profound: what both secular and religious institutions call governance...
Lamott is accustomed to laughing at herself. The essayist and novelist has spent much of the past 30 years chasing profound truths, pinning them to the page and then dousing them with self-deprecating humor. She makes life's terrifying challenges seem small enough to hold in your hand, cameos to contemplate rather than big pictures to overwhelm, whether it's writing a book (Bird by Bird), finding faith (Traveling Mercies) or saying farewell to a loved one (Hard Laughter). See the all TIME 100 novels...
Before Dartek begins, Michael Bay (played by an actor in the Math Department, Robert C. Rogers) gives a profound speech involving life, art, and outer space—and you’ll have to check out the episode to find out what Bay does when his perfect movie screening goes haywire due to some film-swapping chaos. We can tell you one thing though: there are a whole lot of expletives involved...
...high-fat foods changed the functioning of the rats' brain circuitry, making it harder and harder for them to register pleasure - in other words, they developed a type of tolerance often seen in addiction - an effect that got progressively worse as the rats gained more weight. "It was quite profound," says study author Paul Kenny, an associate professor of neuroscience at the Scripps Research Institute. The reward-response effects seen in the fatty-food-eating mice were "very similar to what we see with animals that use cocaine and heroin," he says...