Word: multidrug
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...year than AIDS. Today, the first line of treatment against MRSA is vancomycin, a formidable antibiotic that has been around since the 1950s and is otherwise typically considered a drug of last resort. In the developing world, health workers report a proliferation of XDR (extensively drug-resistant) and MDR (multidrug-resistant) tuberculosis, against which the current first-line antibiotics, rifamycins, developed in the 1960s, have also become useless...
...million people died from it. More alarming is a growing subset of TB cases, estimated at half a million, that are resistant to more than one of the handful of anti-TB drugs. While they still make up only 5% of the total annual TB burden, these cases of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB are mushrooming, fueled by both the surge in H.I.V./AIDS and health systems that have ignored the threat of TB for too long...
...million people died from it. More alarming is a growing subset of TB cases, estimated at half a million, that are resistant to more than one of the handful of anti-TB drugs. While they still make up only 5% of the total annual TB burden, these cases of multidrug-resistant and extensively drug-resistant TB are mushrooming, fueled by the surge in AIDS and by health-care systems that have ignored the threat of TB for too long...
...associate professor at the Harvard School of Public Health (HSPH), co-led the project, which has been ongoing for 15 months. Willem Sturm, the Interim Dean of the Nelson Mandela School of Medicine in South Africa, was the project’s other leader. The project focused on multidrug-resistant tuberculosis (MDR-TB) and a strain of extensively drug-resistant tuberculosis (XDR-TB) that had recently killed 45 people in KwaZulu-Natal. The collection and identification of the strains took place in South Africa, while the scientists at the Broad Institute incubated and sequenced the genes. Although TB genes have...
Doctors are eager to go ahead with multidrug experiments and more extensive tests of existing drugs. "It's terrible going into room upon room of patients who ask what we can do, and to have to tell them we have nothing to offer," says Dr. Donald Abrams, assistant director of the AIDS clinic at San Francisco General Hospital. One major obstacle, researchers agree, is a lack of federal funds. "The Administration is giving lip service to this disease but not the funding," complains Immunologist Allan Goldstein of George Washington University. Federal allocations for AIDS research have risen steadily from...