Word: herceptin
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...findings, published online by the Annals of Oncology, show that oleic acid cuts levels of a cancer-causing gene called her-2neu by 46%. her-2neu affects up to 30% of women with breast cancer. The team found that oleic acid also enhanced the effectiveness of breast-cancer drug Herceptin. Breast cancer is the second-deadliest cancer among women; more than 400,000 died from the disease in 2002, according to the International Agency for Research on Cancer. Ruth Lupu, lead author of the report, said the results "lead us to an exciting path of inquiry about diet and breast...
...body like a little rescue squad, to help produce enzymes that because of some faulty gene, the body can't make on its own. When we finally find cures for cancers, they will reflect the secrets of how our genes fight some cancers and yield to others. Drugs like Herceptin for breast cancer and Gleevec for leukemia work by blocking the chemical signal that tells the cancer to grow. They herald the day when we can look back on the traditional slashing and burning of cancer patients as having been as primitive as bloodletting...
Beth Nocera was a fighter, her husband Louis recalls. She bravely battled breast cancer for six years. She endured surgery, chemotherapy, radiation and multiple drug treatments. She fought to get into a clinical trial for Herceptin, but her previous treatment made her ineligible. She signed up for a lottery that the drug manufacturer had established to distribute its scarce supplies. Her number didn't come up. In July 1998, after nearly a year on a waiting list, she finally got her Herceptin. But by then the cancer was so widespread that Nocera, 41 and the mother of two, was dead...
...OPTIONS Most treatments are aimed at relieving symptoms or prolonging life a few months or years. Surgery or radiation to remove or at least try to shrink any tumors. Chemotherapy. Herceptin for those cancers that express an excess of the Her2 receptor. Tamoxifen or an aromatase inhibitor, if they haven't already been used, for those tumors that respond to estrogen. (Clinical trials of both herceptin and aromatase inhibitors in earlier stages of breast cancer are under...
...AVAILABILITY Herceptin, the first of these smart drugs for breast cancer, is available for certain advanced cancers...