Word: gutterman
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...white-cell counts in AIDS patients. Gamma interferon seems to remedy the defective functioning of monocytes and macrophages in a wide variety of diseases. Alpha interferon has been particularly effective against two types of leukemia and non-Hodgkin's lymphoma, a cancer of the lymph system. Says Dr. Jordan Gutterman, of Houston's M.D. Anderson Hospital and Tumor Institute: "There are ten different tumors in which potentially important anti-tumor activity by interferon has been demonstrated...
Interleukin-2 has shown promising results in treating advanced skin and kidney cancers. In fact, says Gutterman, there appears to be "tremendous synergy" between alpha interferon and IL-2 in attacking cancer cells. While IL-2 works to make the killer cells more potent, he explains, they "have to recognize something unique on the surface of the cancer cell in order to kill it." That something is an antigen, and interferon seems to make it more "visible" to the killer cells...
...made large quantities of these substances available to researchers. Many physicians believe that IL-2, which has also been genetically engineered, will eventually be used together with some of these other substances. "It may be that for each type of cancer, you need a different combination," suggests Dr. Jordan Gutterman, of Houston's M.D. Anderson Hospital and Tumor Institute. IL-2 may also prove useful in combination with standard chemotherapy or as a follow-up to surgery. Stenzel theorized that after such traditional treatments, IL-2 could "gear up the patient's own cells to scavenge any remaining tumor cells...
Undaunted, scientists continued to test the enigmatic substance. "People do not realize how slowly research progresses," says Dr. Jordan Gutterman, a leading interferon investigator at Houston's M.D. Anderson Hospital. "You don't go to the moon on the first rocket." At a meeting of the American Society of Clinical Oncology in Houston, it became clear that interferon has at the very least had a successful launch, and may be beginning to fulfill some of its early promise...
Other students agree. "I think the biggest part of life here is recreation," said Alex Gutterman. "You'll see the school for what it really is on a nice spring day," he added. "There is some really hard-core studying here, too, it just takes place in the libraries where...