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...Though other genes in this pathway have been shown to correlate with [advanced prostate cancer], this gene goes one step farther,” said Harvard Medical School Assistant Professor Karen M. Cichowski, who led the study. Cichowski said the gene DAB2IP plays a direct role in causing prostate cancer to spread...
...study—published Sunday in the journal Nature Medicine—found a strong correlation between lacking the gene DAB2IP and a higher chance of developing prostate cancer in mice. The scientists’ findings were corroborated when they analyzed the tissue samples of hundreds of prostate cancer patients...
...researchers also identified the pathway causing prostate cancer to metastasize—which involves a protein coded by the gene EZH2. Loss of DAB2IP “liberates” EZH2 to drive downstream metastatic genes, researchers said...
...Understanding how this gene [DAB2IP] regulates metastasis at a deeper level...can ultimately lead to a new step in understanding not just prostate cancer, but how metastasis occurs,” said HMS Professor William C. Hahn ’87, an author of the paper...
Both Hahn and Cichowski said they believe that the gene DAB2IP could be an answer to this problem, adding that they hope to see more research devoted to studying the pathway...