Word: fragments
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...when he realized that his unconventional idea of how to find new drugs to attack disease-causing proteins might never be realized unless he pursued it himself. He founded Astex, based in Cambridge, England, so he could develop his own flexible approach to molecular research. He calls it "fragment based," because rather than throwing an entire proposed drug molecule at the target protein, he throws just pieces at a time...
Jhoti and four of his scientists hit the pub when they had their eureka moment. In October 2002 their advanced X-ray and crystal technique revealed that a chemical was binding to a protein that is a possible cause of Alzheimer's disease. The chemical was a fragment of what could eventually become an Alzheimer's-conquering drug. "I first thought the team had played a trick on me," says Jhoti. Drug giant AstraZeneca, which had been searching for such a chemical for years, enlisted Astex's help. In 2003 the company signed a contract to pay Astex $40 million...
...that had eluded better-funded corporate researchers. In October 2002, Jhoti and his colleagues at Astex discovered in their Cambridge lab a chemical that bound to a protein called beta-secretase (Bace), which researchers had identified as a possible cause of Alzheimer's disease. The chemical was just a fragment of what could eventually become an Alzheimer's-conquering drug. But it represented a big step in the quest for a Bace-targeting substance, which drug giant AstraZeneca had been seeking for years; the firm enlisted Astex's help. "AstraZeneca worked on it for four years. We delivered an early...
...Astex calls its drug discovery method "fragment-based,'' because rather than throwing an entire proposed drug molecule at the target protein, they throw just pieces at a time. Jhoti claims this yields a much higher success rate than trying out whole molecules, an approach favored by large drug companies like the one he left in 1999, Glaxo Wellcome...
...roads or popped up in windows. The fight lasted nearly two hours. The young grunts defended themselves with all manner of fire, including AT4 antitank rockets, M-203 40-mm grenade launchers and TOW missiles from the Bradleys supporting them. A young sergeant went down, shrapnel or a bullet fragment lodging in his cheek. After checking himself, he went back to returning fire...