Word: estrogens
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...involved 107,000 women undergoing mastectomy for breast cancer, most women did not obtain a survival benefit from preventive surgery in the unaffected breast. Only a specific group of patients - women under age 50 who had early-stage cancer (I or II) and tumors that were negative for the estrogen receptor - saw an increase in their chances of surviving to five years. That increase was small, just 4.8%, compared with women who did not have preventive mastectomy. Further, less than 10% of the breast-cancer population fits these criteria...
...Anderson study highlights the combined effect of three major factors in improving breast-cancer survival: age, type of tumor and stage of cancer. Taken together, this suite of criteria makes sense, says Bedrosian. Women with estrogen-positive cancers can be treated with hormone-therapy drugs like tamoxifen or, if they are postmenopausal, the new aromatase inhibitors, which block the production of cancer-enhancing estrogen in the body. Women whose tumors lack the estrogen receptor, however, cannot take advantage of these drugs, since their cancers are not as dependent on estrogen for fuel. As a result, they have a lower survival...
...what you eat, how much you exercise - to ensure that you don't increase your risk of developing another tumor. It's a natural response to a difficult diagnosis, but it can be challenging, especially when it comes to diet: most breast tumors are driven by the hormone estrogen, but estrogen is frequently found in many popular foods, from some types of milk and yogurt to breakfast bars to tofu and those addictive edamame beans...
...common culprit is soy, a plant that contains chemicals with estrogen-like and anti-estrogenic properties - making it a nutritional minefield for breast-cancer survivors. While Western diets are relatively low in soy - compared with the typical diet in Asia, where people eat soy daily - the percentage of Americans consuming soy at least once a week increased from 15% in 1997 to 28% in 2003. In the meantime, studies on the effect of soy on breast-cancer recurrence and mortality have been conflicting, with some showing that it can reduce risk, while others show an elevated rate of recurrent disease...
Nikki Walker, 35, an actress in New York City, stopped taking the Pill because of concerns about the effects of excess estrogen on her body and the environment. "I do yoga every day and eat vegetarian," she says. "Why wouldn't I go green in this area of my life...